Targeted disruption of NF-κB1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling
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Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling.
NF-kappaB-mediated proinflammatory response to cigarette smoke (CS) plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). The heterodimer of RelA/p65-p50 (subunits of NF-kappaB) is involved in transactivation of NF-kappaB-dependent genes, but interestingly p50 has no transactivation domain. The endogenous role of p50 subunit, particularly in regulation of CS-...
متن کاملTargeted disruption of NF- B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling
Rajendrasozhan S, Chung S, Sundar IK, Yao H, Rahman I. Targeted disruption of NFB1 (p50) augments cigarette smokeinduced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling. Am J Physiol Lung Cell Mol Physiol 298: L197–L209, 2010. First published December 4, 2009; doi:10.1152/ajplung.00265.2009.—NFB-mediated proinflammatory response to cigarette smoke (CS) pl...
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William C. Sha,* Hsiou-Chi Liou,t Elaine I. Tuomanen,~ and David Baltimore* *Department of Biology Massachusetts Institute of Technology Cambridge, Massachusetts 02139 tDepartments of Cell Biology and Medicine Division of Allergy and Immunology Cornell University Medical College New York, New York 10021 ~Laboratory of Molecular Infectious Diseases The Rockefeller University New York, New York 1...
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The dimeric transcription factor nuclear factor-kappaB (NF-kappaB) regulates several endogenous sleep-modulatory substances and thereby serves as a pivotal mediator of sleep-wake homeostasis. To further define the role of NF-kappaB in sleep regulation, we monitored sleep and temperature in mice that lack the p50 subunit of NF-kappaB [p50 knockout (KO) mice]. Compared with the control B6129PF2/J...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2010
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00265.2009